PBS-listed for type 2 diabetes as add-on therapy — dulaglutide once weekly, no titration. Initiation gate: contraindication/intolerance to an SGLT2 inhibitor, or no clinically meaningful glycaemic response to one. Verify current criteria at pbs.gov.au.
1Eligibility — who qualifies on the PBS
✓Diagnosis — Type 2 diabetes mellitus — not type 1, LADA, MODY or gestational diabetes.
✓SGLT2i criterion — Contraindication/intolerance requiring discontinuation of an SGLT2 inhibitor, or no clinically meaningful glycaemic response to one (PBAC, June 2024).
✓Combination — With at least one of metformin, a sulfonylurea or insulin. Not with another GLP-1 RA, an SGLT2i for diabetes, or a DPP-4i.
✓Authority — Initiation: Authority Required — phone 1800 888 333 or PBS Online / HPOS. Continuation: Streamlined (no phone call).
2When to choose Trulicity (vs other GLP-1 RAs)
✓Established CVD — REWIND: ~12% reduction in major CV events across the risk spectrum, including primary prevention.
✓Renal protection — REWIND: ~15% reduction in a composite renal outcome; no dose adjustment, usable to eGFR 15.
✓Simpler dosing — No titration — start at the maintenance dose from week 1, unlike semaglutide.
✓Once-weekly dose — Fixed once-weekly injection. Confirm available strengths at pbs.gov.au.
3Continuation / renewal — document at each renewal
- Clinical benefit — HbA1c reduction, weight reduction, or improved glycaemic control.
- No new contraindications, and still on an eligible combination (metformin, a sulfonylurea, or insulin).
Safety
- Not for type 1 diabetes, LADA or gestational diabetes.
- MEN2 / medullary thyroid cancer (personal or family history) — class effect.
- Acute pancreatitis, active or past — withhold; specialist input before any restart.
- Cease before a planned pregnancy (TGA category B3).
Check / exclude
- Confirm still on an eligible combination at each renewal.
- Not with another GLP-1 RA, an SGLT2i for diabetes, or a DPP-4i.
- Hypoglycaemia risk rises with insulin or a sulfonylurea — consider a dose reduction.
- Re-verify the current PBS restriction at pbs.gov.au.
DE-02 v1.1 · Reviewed Jun 2026 · Review Dec 2026
For health-professional use. Summary only — not a substitute for the current PBS Schedule or the approved product information. Verify eligibility, restriction level and authority requirements at pbs.gov.au before prescribing. PBS criteria change frequently.
